|
|
Job ID: 4554
Employer: Helicon Therapeutics
Position: Scientist
Description: Helicon Therapeutics is seeking a Bioanalytical Chemistry Scientist experienced in quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic and in vitro ADME analyses of novel small molecule therapeutics. The successful candidate will have strong technical expertise in bioanalysis using LC-MS/MS systems and other bioanalytical methods (UV, fluorescence, etc.). Expertise in in vivo and in vitro pharmacokinetics is required, with a strong background in modeling of pk data using compartmental and noncompartmental models.
Primary responsibilities include developing bioanalytical LC-MS/MS methods for the quantitative analysis of small molecule drugs, quantitating drug concentrations in various biological matrices, modeling of pk data. The successful candidate will also establish and validate various in vitro metabolic stability, cytochrome P450 and other DMPK assays. Experience with cell culture, automation platforms and permeability studies are a plus. The ability to work independently and manage research associates is required as are good communication and presentation skills
Requirements: • PhD degree in bioanalytical chemistry and 2+ years of industrial experience
• Extensive knowledge of DMPK science and experience in applying DMPK concepts to drug discovery and drug development
• Strong expertise in theoretical and practical pk concepts and ability to accurate model in vivo and in vitro data
• Experience in developing and troubleshooting LC-MS/MS methods and instrumentation
• Good organizational, record keeping, presentation and communication skills
• Enthusiasm and motivated team player with a can-do attitude
Location: San Diego, CA
Contact: rmenezes@helicontherapeutics.com
Post Date: 7/16/2010 12:54:54 PM
|
|